OT: Coronavirus

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@purplefaithful said:
First drug proves able to improve survival from COVID-19

By MARILYNN MARCHIONE Associated PressJune 16, 2020 — 8:05am

Researchers in England say they have the first evidence that a drug can improve COVID-19 survival: A cheap, widely available steroid called dexamethasone reduced deaths by up to one third in severely ill hospitalized patients.
Results were announced Tuesday and researchers said they would publish them soon. The study is a large, strict test that randomly assigned 2,104 patients to get the drug and compared them with 4,321 patients getting only usual care.
The drug was given either orally or through an IV. After 28 days, it had reduced deaths by 35% in patients who needed treatment with breathing machines and by 20% in those only needing supplemental oxygen. It did not appear to help less ill patients.
"This is an extremely welcome result," one study leader, Peter Horby of the University of Oxford, said in a statement. "The survival benefit is clear and large in those patients who are sick enough to require oxygen treatment, so dexamethasone should now become standard of care in these patients. Dexamethasone is inexpensive, on the shelf, and can be used immediately to save lives worldwide."
Even though the drug only helps in severe cases, "countless lives will be saved globally," said Nick Cammack of Wellcome, a British charity that supports science research.
"Dexamethasone must now be rolled out and accessed by thousands of critically ill patients around the world," said Cammack, who had no role in the study. "It is highly affordable, easy to make, can be scaled up quickly and only needs a small dosage."
Steroid drugs reduce inflammation, which sometimes develops in COVID-19 patients as the immune system overreacts to fight the infection. This overreaction can prove fatal, so doctors have been testing steroids and other anti-inflammatory drugs in such patients. The World Health Organization advises against using steroids earlier in the course of illness because they can slow the time until patients clear the virus.
Researchers estimated that the drug would prevent one death for every eight patients treated while on breathing machines and one for every 25 patients on extra oxygen alone.
This is the same study that earlier this month showed the malaria drug hydroxychloroquine was not working against the coronavirus. The study enrolled more than 11,000 patients in England, Scotland, Wales and Northern Ireland who were given either standard of care or that plus one of several treatments: dexamethasone; the HIV combo drug lopinavir-ritonavir, the antibiotic azithromycin; the anti-inflammatory drug tocilizumab; or plasma from people who have recovered from COVID-19 that contains antibodies to fight the virus.
Research is continuing on the other treatments. The research is funded by government health agencies in the United Kingdom and private donors including the Bill and Melinda Gates Foundation.

There was a doctor that (early on) recognized that patients with near  end-stage infections miraculously benefitted from anti-inflammatory (steroid) treatment.  Anecdotal...not peer-reviewed studied...but there wasn't time for that, at the time. 

Dr Yadegar @ Cedars-Sinai in LA.  


https://www.nbclosangeles.com/news/coron...m/2341382/
 

He was the first (I believe, in early April) that Id'd  the problem with advanced Chinese Virus patients who weren't being helped by 'intubation'/ventilators, but saved by stopping the "cytokine storm".  The cytokine storm, is the body's natural reaction to infection/inflammation, which can be powerful (and destructive).  Sometimes so powerful, it can be worse than the antigen/inflammator.  

This needs to be studied/peer reviewed, etc...but nice to have another (potential) clinical remedy in the clinical toolbox.  

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[Guest]

@Ralphie said:

LMAO. Hilarious. 

[Guest]

@savannahskol said:

@purplefaithful said:
First drug proves able to improve survival from COVID-19

By MARILYNN MARCHIONE Associated PressJune 16, 2020 — 8:05am

Researchers in England say they have the first evidence that a drug can improve COVID-19 survival: A cheap, widely available steroid called dexamethasone reduced deaths by up to one third in severely ill hospitalized patients.
Results were announced Tuesday and researchers said they would publish them soon. The study is a large, strict test that randomly assigned 2,104 patients to get the drug and compared them with 4,321 patients getting only usual care.
The drug was given either orally or through an IV. After 28 days, it had reduced deaths by 35% in patients who needed treatment with breathing machines and by 20% in those only needing supplemental oxygen. It did not appear to help less ill patients.
"This is an extremely welcome result," one study leader, Peter Horby of the University of Oxford, said in a statement. "The survival benefit is clear and large in those patients who are sick enough to require oxygen treatment, so dexamethasone should now become standard of care in these patients. Dexamethasone is inexpensive, on the shelf, and can be used immediately to save lives worldwide."
Even though the drug only helps in severe cases, "countless lives will be saved globally," said Nick Cammack of Wellcome, a British charity that supports science research.
"Dexamethasone must now be rolled out and accessed by thousands of critically ill patients around the world," said Cammack, who had no role in the study. "It is highly affordable, easy to make, can be scaled up quickly and only needs a small dosage."
Steroid drugs reduce inflammation, which sometimes develops in COVID-19 patients as the immune system overreacts to fight the infection. This overreaction can prove fatal, so doctors have been testing steroids and other anti-inflammatory drugs in such patients. The World Health Organization advises against using steroids earlier in the course of illness because they can slow the time until patients clear the virus.
Researchers estimated that the drug would prevent one death for every eight patients treated while on breathing machines and one for every 25 patients on extra oxygen alone.
This is the same study that earlier this month showed the malaria drug hydroxychloroquine was not working against the coronavirus. The study enrolled more than 11,000 patients in England, Scotland, Wales and Northern Ireland who were given either standard of care or that plus one of several treatments: dexamethasone; the HIV combo drug lopinavir-ritonavir, the antibiotic azithromycin; the anti-inflammatory drug tocilizumab; or plasma from people who have recovered from COVID-19 that contains antibodies to fight the virus.
Research is continuing on the other treatments. The research is funded by government health agencies in the United Kingdom and private donors including the Bill and Melinda Gates Foundation.

There was a doctor that (early on) recognized that patients with near  end-stage infections miraculously benefitted from anti-inflammatory (steroid) treatment.  Anecdotal...not peer-reviewed studied...but there wasn't time for that, at the time. 

Dr Yadegar @ Cedars-Sinai in LA.  


https://www.nbclosangeles.com/news/coron...m/2341382/
 

He was the first (I believe, in early April) that Id'd  the problem with advanced Chinese Virus patients who weren't being helped by 'intubation'/ventilators, but saved by stopping the "cytokine storm".  The cytokine storm, is the body's natural reaction to infection/inflammation, which can be powerful (and destructive).  Sometimes so powerful, it can be worse than the antigen/inflammator.  

This needs to be studied/peer reviewed, etc...but nice to have another (potential) clinical remedy in the clinical toolbox.  

There's been discussion in medical communities here at HCMC re steroidal treatment, but this may cement its use once the peer review is finished...

Really? You're sticking with China virus? Even the POTUS has moved on from that one.

[Guest]

@Ralphie said:

I think you and I visit some of the same sites for material. =)

[Guest]

@JimmyinSD said:

@Ralphie said:

I think you and I visit some of the same sites for material. =)

Then you probably saw this....

[Guest]

@Ralphie said:

@JimmyinSD said:

@Ralphie said:

I think you and I visit some of the same sites for material. =)

Then you probably saw this....

Even that's better than what most people had on their faces on my last trip to Wal-Mart: nothing.  Idiots.

[Guest]

And Chris Hansen is back from the journalistically dead with this hour-long report on how New Yorkers have been fighting COVID and frequently the bureaucracy.  Lots of ads (hey, it's a Youtube channel) but interesting stuff:

[Guest]

@Ralphie said:

@JimmyinSD said:

@Ralphie said:

I think you and I visit some of the same sites for material. =)

Then you probably saw this....

It does make it easier as the fudge stripe always goes on the outside. 

[Guest]

https://twitter.com/SportsCenter/status/...38945?s=19